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KMID : 1225720160080060535
Allergy, Asthma & Immunology Research : AAIR
2016 Volume.8 No. 6 p.535 ~ p.540
A Multicenter Retrospective Case Study of Anaphylaxis Triggers by Age in Korean Children
Lee So-Yeon

Kim Ji-Hyun
Jang Gwang-Cheon
Min Taek-Ki
Kwon Ji-Won
Sohn Myung-Hyun
Kim Kyung-Won
Kim Kyu-Earn
Yu Jin-Ho
Hong Soo-Jong
Kwon Jung-Hyun
Kim Sung-Won
Song Tae-Won
Kim Woo-Kyung
Kim Hyung-Young
Jeon You-Hoon
Lee Yong-Ju
Lee Hae-Ran
Kim Hye-Young
Ahn Young-Min
Yum Hye-Yung
Suh Dong-In
Kim Hyun-Hee
Kim Jin-Tack
Kim Jeong-Hee
Park Yong-Mean
Lee Soo-Young
Yang Hyeon-Jong
Pyun Bok-Yang
Abstract
Purpose:Although anaphylaxis is recognized as an important, life-threatening condition, data are limited regarding its triggers in different age groups. We aimed to identify anaphylaxis triggers by age in Korean children.

Methods:We performed a retrospective review of medical records for children diagnosed with anaphylaxis between 2009 and 2013 in 23 secondary or tertiary hospitals in South Korea.

Results:A total of 991 cases (mean age=5.89¡¾5.24) were reported, with 63.9% involving patients younger than 6 years of age and 66% involving male children. Food was the most common anaphylaxis trigger (74.7%), followed by drugs and radiocontrast media (10.7%), idiopathic factors (9.2%), and exercise (3.6%). The most common food allergen was milk (28.4%), followed by egg white (13.6%), walnut (8.0%), wheat (7.2%), buckwheat (6.5%), and peanut (6.2%). Milk and seafood were the most common anaphylaxis triggers in young and older children, respectively. Drug-triggered anaphylaxis was observed more frequently with increasing age, with antibiotics (34.9%) and nonsteroidal anti-inflammatory drugs (17.9%) being the most common causes.

Conclusions:The most common anaphylaxis trigger in Korean children was food. Data on these triggers show that their relative frequency may vary by age.
KEYWORD
Anaphylaxis, children, epidemiology
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